Beilstein J. Org. Chem.2019,15, 801–810, doi:10.3762/bjoc.15.77
the versatility of our approach.
Keywords: acyclicnucleosidephosphonate; adefovir; alkylation; antiviral; N-alkylation; purine; Introduction
The acyclicnucleosidephosphonate adefovir (1) [1], administered as its dipivoxil prodrug form (2) [2], is used clinically for the treatment of infections